536: Distinct mechanisms of senescence activation in amnion by infection, inflammation and oxidative stress
نویسندگان
چکیده
منابع مشابه
Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro
Objective(s): Naringin, an essential flavonoid, inhibits inflammatory response and oxidative stress in diabetes. However, whether naringin has beneficial effects on diabetic retinopathy (DR) remains unknown. Materials and Methods: Streptozotocin (STZ, 65 mg/kg) was intraperitoneally injected into male rats (8 weeks old weighting 200-250 g) to establish diabetic model, then naringin (20, 40 or 8...
متن کاملOxidative Stress Mechanisms during Flower Senescence
Free radicals and other active derivatives of oxygen are inevitable by-products of biological redox reactions and universal under stress situations. Reactive oxygen species inactivate enzymes and damage important cellular processes and subsequently cell components also. Plants and other organisms have evolved a wide range of mechanisms to contend with this problem by promoting the synthesis of ...
متن کاملRRM2B Suppresses Activation of the Oxidative Stress Pathway and is Up-regulated by P53 During Senescence
RRM2B is the DNA damage-inducible small subunit of ribonucleotide reductase, the rate-limiting enzyme in de novo deoxyribonucleoside triphosphate synthesis. Although RRM2B is implicated in DNA repair and the maintenance of mitochondrial DNA content, the regulation and function of RRM2B in senescence have not been previously established. Here, we show that RRM2B is highly induced in a p53-depend...
متن کاملThe effects of creatine and carnitine supplementation on oxidative stress and inflammation in athletes
Introduction: The present study was carried out to evaluate the effects of creatine and carnitine supplementation on oxidative stress and inflammation in athletes. Methods: In this single-blind randomized clinical trial 45 sportsmen were studied selected from Velayat Sports Complex (in Shiraz) in this single-blind randomized clinical trial. Then they were randomly divided into four groups suppl...
متن کاملTime course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats
Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2017
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2016.11.271